The test measures six important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers.
Metabolites are what the bodies liver makes from what you have eaten or what has been metabolized from birth control pills or hormone replacement therapies or after a host of other estrogen toxic substances such as hormone in the meat, dairy and plastics! Plastics lead to having Bisphenol A in your body. Bisphenol A Profile is another urine test you can have done to test for hormone disruptors like BPA, triclosan, and 4-nonylphenol.
The Estronex Profile measures six important estrogen metabolites, and ratios, including:
The "Good" Estrogen
- 2-hydroxyestrone (2-OHE1) - high levels of 2-OHE1 are ideal to reduce cancer growth.
- 2-hydroxyestradiol (2-OHE2) - shown to exhibit anti-carcinogenic effects.
- 2-methoxyestrone (2-OMeE1) - OMeE1 has shown to have anticancer effects and is ideal in high levels.
- 4-methoxyestrone (4-OMeE1) - as a non-cancerous metabolite, OMeE1 generally does not require treatment at high levels in the body.
The "Bad" Estrogen
- 16-α-hydroxyestrone (16α-OHE1) - also considered a "bad" estrogen, 16α-OHE1 in high levels may encourage tumor development.
- 2-OHE:16α-OHE1 (2:16 ratio) - 2:16 ratios less than 2.0 indicate increasing long-term risk for breast, cervical, and other estrogen sensitive cancers. Importantly, nutritional interventions can help raise Estronex 2:16 ratios and decrease long-term risk. Studies also indicate that this risk is modifiable!
- 2-OHE1:2-OMeE1 - a high level of 2-OHE1:2-OMeE1 may also indicate imbalanced estrogen metabolism and low activity in the COMT gene. Evaluation of methylation activity is recommended.
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